GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE268nnn/GSE268194/primaryOK200OtherHomo sapiensOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE268194GEOGSEfalseIdentification of the RNA that binds with FAK by high-throughput RIP-seq in MDA-MB-231 cellsFAK is overexpressed and aberrantly activated in various advanced solid tumors and plays a critical role in tumor progression and metastasis. Here, we identified an FAK-interacting lncRNA FAISL, FAISL (FAK Interacting and Stabilizing LncRNA) was frequently overexpressed in TNBC tissues and abundantly enriched in FAK-interacting lncRNAs. FAISL promotes cell adhesion, cytoskeleton spreading, proliferation and anchor-dependent survival of TNBC cells. FAISL doesn’t affect FAK mRNA but positively regulates the FAK protein level by blocking Calpain 2-mediated proteolysis, etc.2026/05/01GSE268194GSM8287593GSM8287592GSM828759124676268194Homo sapiens