{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE268nnn/GSE268626/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE268626"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Systemic reprogramming of monocytes in Crohn’s disease promotes their intestinal inflammatory function","description":"Dysfunctional intestinal monocyte-derived macrophages contribute to pathology in Inflammatory Bowel Disease (IBD). Signals from the tissue micro-environment contribute to this dysfunction, however growing evidence suggests that monocytes can be primed for inflammatory function prior to tissue recruitment. Here we use single cell RNA sequencing (scRNA-seq) to define blood monocyte heterogeneity in a cohort of newly diagnosed, treatment naive Crohn’s disease and Ulcerative Colitis patients and healthy controls, and to establish the scope of of IBD-associated transcriptional changes in monocyte populations prior to arrival in the intestine.","dates":{"publication":"2026/07/23"},"accession":"GSE268626","cross_references":{"GSM":["GSM8295520","GSM8295531","GSM8295521","GSM8295532","GSM8295522","GSM8295523","GSM8295530","GSM8295517","GSM8295528","GSM8295529","GSM8295518","GSM8295519","GSM8295524","GSM8295513","GSM8295525","GSM8295514","GSM8295526","GSM8295515","GSM8295527","GSM8295516"],"GPL":["24676"],"GSE":["268626"],"taxon":["Homo sapiens"]}}