GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE268nnn/GSE268626/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE268626GEOGSEfalseSystemic reprogramming of monocytes in Crohn’s disease promotes their intestinal inflammatory functionDysfunctional intestinal monocyte-derived macrophages contribute to pathology in Inflammatory Bowel Disease (IBD). Signals from the tissue micro-environment contribute to this dysfunction, however growing evidence suggests that monocytes can be primed for inflammatory function prior to tissue recruitment. Here we use single cell RNA sequencing (scRNA-seq) to define blood monocyte heterogeneity in a cohort of newly diagnosed, treatment naive Crohn’s disease and Ulcerative Colitis patients and healthy controls, and to establish the scope of of IBD-associated transcriptional changes in monocyte populations prior to arrival in the intestine.2026/07/23GSE268626GSM8295520GSM8295531GSM8295521GSM8295532GSM8295522GSM8295523GSM8295530GSM8295517GSM8295528GSM8295529GSM8295518GSM8295519GSM8295524GSM8295513GSM8295525GSM8295514GSM8295526GSM8295515GSM8295527GSM829551624676268626Homo sapiens