GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE268nnn/GSE268780/primaryOK200TranscriptomicsDanio rerioExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE268780GEOGSEfalseFibronectin mediates the interaction between vascular pathology and Alzheimer’s disease by inhibiting homeostatic gliovascular crosstalkAlzheimer's disease (AD) often coexists with cerebrovascular pathology (CVP), contributing to cognitive decline and dementia. Understanding the molecular interplay between these pathologies is vital for developing effective therapies that can address the complexities of AD. The extracellular matrix (ECM) plays a crucial role in maintaining the blood-brain barrier (BBB) and modulating interactions of brain cell types with the vasculature. Elevated levels of a particular ECM component, Fibronectin 1 (FN1) are associated with both AD and vascular dysfunctions. In this study we show the molecular regulation exerted by FN1 to regulate the homeostatic interaction between vasculature and the brain.2026/07/02GSE268780GSM8299023GSM829902220828268780Danio rerio