{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269410/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE269410"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"High-resolution transcriptomic profiles of kidney distal convoluted tubules in male and female mice","description":"Sexual dimorphic responses to physiological factors in the kidney have been emerging as important considerations for understanding kidney physiology and pathophysiology. Here, we report high-resolution transcriptome profiles of distal convoluted tubules isolated from the kidneys of male and female mice. Transcriptomic analysis based on RNA-Seq cooupled with tubule microdissection was carried out in male and female mice. To accurately isolate the early DCT (DCT1) segments, microdissection was performed in a Pvalb-cre tdTomato transgenic mouse model. Transcript profiles in male and female DCT1 segments revealed comprehensive sex differences in the molecular features of the early DCT segments. Our data provide a high-resolution DCT1 (early DCT) transcriptome and serve as a reference resource for DCT research.","dates":{"publication":"2026/06/30"},"accession":"GSE269410","cross_references":{"GSM":["GSM8314633","GSM8314632","GSM8314631","GSM8314630","GSM8314629","GSM8314628","GSM8314627","GSM8314626","GSM8314636","GSM8314625","GSM8314635","GSM8314624","GSM8314634"],"GPL":["24247"],"GSE":["269410"],"taxon":["Mus musculus"]}}