{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Xlsx":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269428/suppl/GSE269428_counts_set1.xlsx","ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269428/suppl/GSE269428_counts_set3.xlsx","ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269428/suppl/GSE269428_counts_set2.xlsx"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269428/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE269428"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"PBRM1 RNA-seq","description":"Mammalian SWI/SNF or BAF are multi-subunit complexes that regulate cell-type specific gene expression by modulating chromatin accessibility, in coordination with transcription factors and other chromatin regulators. PBRM1 is the complex defining subunit of PBAF class of SWI/SNF complexes. It is mutated in ~40% of clear cell renal cell carcinoma cases but also associated with cancer progression and therapy resistance, indicating context-dependent function. We have previously reported that loss of PBRM1 in normal epithelial cells results in a partial Epithelial-to-Mesenchymal Transition (EMT). In this study, we have utilized epigenomic and transcriptomic approaches to understand the mechanistic role of PBRM1 in EMT-regulated gene expression, and its relationship to genome-wide histone modifications.","dates":{"publication":"2026/06/16"},"accession":"GSE269428","cross_references":{"GSM":["GSM8315448","GSM8315449","GSM8315440","GSM8315441","GSM8315442","GSM8315443","GSM8315444","GSM8315445","GSM8315446","GSM8315447","GSM8315437","GSM8315438","GSM8315439","GSM8315473","GSM8315474","GSM8315430","GSM8315431","GSM8315475","GSM8315432","GSM8315433","GSM8315434","GSM8315435","GSM8315436","GSM8315470","GSM8315471","GSM8315472","GSM8315426","GSM8315427","GSM8315428","GSM8315429","GSM8315462","GSM8315463","GSM8315420","GSM8315464","GSM8315465","GSM8315421","GSM8315422","GSM8315466","GSM8315423","GSM8315467","GSM8315468","GSM8315424","GSM8315425","GSM8315469","GSM8315460","GSM8315461","GSM8315459","GSM8315416","GSM8315417","GSM8315418","GSM8315419","GSM8315451","GSM8315452","GSM8315453","GSM8315454","GSM8315455","GSM8315456","GSM8315457","GSM8315458","GSM8315450"],"GPL":["24247"],"GSE":["269428"],"taxon":["Mus musculus"]}}