GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269428/suppl/GSE269428_counts_set1.xlsxftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269428/suppl/GSE269428_counts_set3.xlsxftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269428/suppl/GSE269428_counts_set2.xlsxftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269428/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE269428GEOGSEfalsePBRM1 RNA-seqMammalian SWI/SNF or BAF are multi-subunit complexes that regulate cell-type specific gene expression by modulating chromatin accessibility, in coordination with transcription factors and other chromatin regulators. PBRM1 is the complex defining subunit of PBAF class of SWI/SNF complexes. It is mutated in ~40% of clear cell renal cell carcinoma cases but also associated with cancer progression and therapy resistance, indicating context-dependent function. We have previously reported that loss of PBRM1 in normal epithelial cells results in a partial Epithelial-to-Mesenchymal Transition (EMT). In this study, we have utilized epigenomic and transcriptomic approaches to understand the mechanistic role of PBRM1 in EMT-regulated gene expression, and its relationship to genome-wide histone modifications.2026/06/16GSE269428GSM8315448GSM8315449GSM8315440GSM8315441GSM8315442GSM8315443GSM8315444GSM8315445GSM8315446GSM8315447GSM8315437GSM8315438GSM8315439GSM8315473GSM8315474GSM8315430GSM8315431GSM8315475GSM8315432GSM8315433GSM8315434GSM8315435GSM8315436GSM8315470GSM8315471GSM8315472GSM8315426GSM8315427GSM8315428GSM8315429GSM8315462GSM8315463GSM8315420GSM8315464GSM8315465GSM8315421GSM8315422GSM8315466GSM8315423GSM8315467GSM8315468GSM8315424GSM8315425GSM8315469GSM8315460GSM8315461GSM8315459GSM8315416GSM8315417GSM8315418GSM8315419GSM8315451GSM8315452GSM8315453GSM8315454GSM8315455GSM8315456GSM8315457GSM8315458GSM831545024247269428Mus musculus