{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE270nnn/GSE270125/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE270125"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency [CUT&Run]","description":"Medulloblastoma (MB) is a biologically heterogeneous childhood cerebellar tumor harboring frequent chromatin-modifying gene alterations. How these alterations promote transcriptional programs governing malignancy remains poorly defined. To address this knowledge gap, we evaluated chromatin states across MB subgroups by multi-modal integration of histone modifications with mutational, DNA methylation, and transcriptomic profiles. A bivalent/poised enhancer (EnhBiv) state was specifically enriched at the promoters of neurodevelopmental genes in Groups 3 and 4-MB. Integrative bioinformatics coupled with chromatin occupancy studies identified aberrant KDM2B binding at EnhBiv-enriched promoters. CRISPR-mediated knockout or acute protein degradation of KDM2B selectively suppressed the growth of MB models in vitro and in vivo. Mechanistically, KDM2B promotes sequential recruitment of Polycomb repressive complexes (PRC1/PRC2) and EnhBiv chromatin, thereby repressing neuronal differentiation programs. Collectively, we provide foundational insights into an epigenetic basis of MB, nominating KDM2B as a selective dependency in high-risk subgroups that warrants consideration as a candidate therapeutic target.","dates":{"publication":"2026/06/26"},"accession":"GSE270125","cross_references":{"GSM":["GSM9570088","GSM9570121","GSM9570089","GSM9570122","GSM9570086","GSM9570120","GSM9570087","GSM9570125","GSM9570126","GSM9570123","GSM9570124","GSM9570080","GSM9570081","GSM9570084","GSM9570085","GSM9570082","GSM9570083","GSM9570118","GSM9570119","GSM9570116","GSM9570117","GSM9570132","GSM9570099","GSM9570133","GSM9570097","GSM9570130","GSM9570131","GSM9570098","GSM9570136","GSM9570137","GSM9570134","GSM9570135","GSM9570091","GSM8334856","GSM8334857","GSM9570092","GSM8334858","GSM9570090","GSM8334859","GSM9570095","GSM9570096","GSM9570093","GSM9570094","GSM9570129","GSM9570127","GSM9570128","GSM9570143","GSM8334860","GSM9570144","GSM9570141","GSM8334861","GSM8334862","GSM9570142","GSM8334900","GSM8334867","GSM8334901","GSM8334868","GSM8334869","GSM8334902","GSM8334903","GSM8334863","GSM9570140","GSM8334864","GSM8334865","GSM8334866","GSM9570138","GSM9570139","GSM8334870","GSM8334871","GSM8334872","GSM8334873","GSM8334911","GSM8334878","GSM8334912","GSM8334879","GSM8334913","GSM8334914","GSM8334874","GSM8334875","GSM8334876","GSM8334877","GSM8334910","GSM8334908","GSM8334909","GSM8334904","GSM8334905","GSM8334906","GSM8334907","GSM8334881","GSM8334882","GSM8334883","GSM8334884","GSM9570048","GSM9570049","GSM8334880","GSM8334889","GSM8334922","GSM8334923","GSM8334924","GSM8334925","GSM8334885","GSM8334886","GSM8334920","GSM8334887","GSM8334888","GSM8334921","GSM8334919","GSM8334915","GSM8334916","GSM8334917","GSM8334918","GSM8334892","GSM9570055","GSM8334893","GSM9570056","GSM8334894","GSM9570053","GSM9570054","GSM8334895","GSM9570059","GSM9570057","GSM8334890","GSM8334891","GSM9570058","GSM9570051","GSM8334896","GSM8334897","GSM9570052","GSM8334898","GSM9570050","GSM8334899","GSM8334926","GSM8334927","GSM9570066","GSM9570067","GSM9570100","GSM9570064","GSM9570065","GSM9570103","GSM9570104","GSM9570068","GSM9570101","GSM9570069","GSM9570102","GSM9570062","GSM9570063","GSM9570060","GSM9570061","GSM9570077","GSM9570110","GSM9570111","GSM9570078","GSM9570075","GSM9570076","GSM9570114","GSM9570115","GSM9570112","GSM9570079","GSM9570113","GSM9570070","GSM9570073","GSM9570074","GSM9570071","GSM9570072","GSM9570107","GSM9570108","GSM9570105","GSM9570106","GSM9570109"],"GPL":["24676"],"GSE":["270125"],"taxon":["Homo sapiens"]}}