{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE270nnn/GSE270211/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE270211"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome analysis of TNFα or necroptosis-induced stimulation in the NCI-H441 cell line with RIPK3 knocked down by siRNA.","description":"We aimed to elucidate the role of RIPK3 in lung adenocarcinoma by analyzing expression variations through RNA sequencing. To achieve this, we suppressed the expression of RIPK3 in the NCI-H441 lung adenocarcinoma cell line, which highly expresses this gene, using multiple siRNAs. We then subjected the cells with RIPK3 knockdown to TNFα stimulation and necroptosis-inducing stimuli. As a result, we observed changes in the expression of genes involved in chemokine expression and the production of interferons (IFNs)","dates":{"publication":"2026/04/01"},"accession":"GSE270211","cross_references":{"GSM":["GSM8336883","GSM8336875","GSM8336880","GSM8336882","GSM8336881","GSM8336877","GSM8336876","GSM8336879","GSM8336878"],"GPL":["24676"],"GSE":["270211"],"taxon":["Homo sapiens"]}}