GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE270nnn/GSE270211/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE270211GEOGSEfalseTranscriptome analysis of TNFα or necroptosis-induced stimulation in the NCI-H441 cell line with RIPK3 knocked down by siRNA.We aimed to elucidate the role of RIPK3 in lung adenocarcinoma by analyzing expression variations through RNA sequencing. To achieve this, we suppressed the expression of RIPK3 in the NCI-H441 lung adenocarcinoma cell line, which highly expresses this gene, using multiple siRNAs. We then subjected the cells with RIPK3 knockdown to TNFα stimulation and necroptosis-inducing stimuli. As a result, we observed changes in the expression of genes involved in chemokine expression and the production of interferons (IFNs)2026/04/01GSE270211GSM8336883GSM8336875GSM8336880GSM8336882GSM8336881GSM8336877GSM8336876GSM8336879GSM833687824676270211Homo sapiens