{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE270nnn/GSE270500/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE270500"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"NK Cell Dysregulation May Potentiate Cardiovascular Disease in Adolescents with Perinatally Acquired HIV on Antiretroviral Therapy","description":"Perinatally acquired HIV (PHIV) and antiretroviral therapy (ART) can alter innate immune cells, (monocytes and natural killer [NK] cells) which are important in the pathogenesis of cardiovascular disease (CVD). We compared cardiovascular biomarkers and immune signatures between PHIV adolescents on suppressive ART and HIV-unexposed, uninfected adolescents in Uganda. Carotid intima-media thickness (IMT) was increased in PHIV, suggesting a higher CVD risk. Flow cytometry analysis revealed greater activation, memory, and migratory capabilities of NK cells, and increased pro-inflammatory intermediate monocytes in PHIV, and these were supported by transcriptomics. Many of these innate immune cell subsets displayed associations with carotid IMT. Plasma oxidized-LDL (Ox-LDL) was significantly lower among PHIVs, and negatively correlated with pro-inflammatory, memory-like NK subsets. We demonstrated increased uptake of Ox-LDL by macrophages in the presence of activated, memory-like NK cells in vitro, suggesting a possible mechanism for greater CVD risk in PHIV. Collectively, our data demonstrate associations between dysregulated NK cell signatures and increased CVD risk among PHIV adolescents.","dates":{"publication":"2026/06/09"},"accession":"GSE270500","cross_references":{"GSM":["GSM8345292","GSM8345293","GSM8345290","GSM8345291","GSM8345296","GSM8345297","GSM8345294","GSM8345295","GSM8345300","GSM8345289","GSM8345287","GSM8345298","GSM8345299","GSM8345288"],"GPL":["24676"],"GSE":["270500"],"taxon":["Homo sapiens"]}}