GEOTranscriptomicsPseudomonas aeruginosaExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE270548GEOGSEfalsePerception of a quorum sensing signal by cell surface immune receptors increases plant disease resistanceBacterial quorum sensing (QS) during pathogenesis is an indicator of increasing danger. How sessile plants perceive QS for defense is unclear. Here, we show that Arabidopsis thaliana perceives 2'-aminoacetophenone (2’-AA), a volatile QS signal from Pseudomonas aeruginosa, through cell surface pattern recognition receptor (PRR) complexes, resulting in multistrategic defense and disease resistance. The 2’-AA-induced plant immunity requires chemical and genetic specificity. 2’-AA binds to the cytoplasmic domain of BRI1-ASSOCIATED RECEPTOR KINASE1 (BAK1) and induces the formation of PRR complexes that initiate the plant immune responses. 2’-AA stimulates plant exudation of acetic acid, a volatile compound that effectively quenches QS and inhibits P. aeruginosa virulence. Plants exposed to 2’-AA reshaped the root microbiome by suppressing the abundant Pseudomonad taxa with increased bacterial diversity. These results illustrate the ability of plants to perceive and respond to pathogen QS.2026/04/16GSE270548GSM8346509GSM8346510GSM8346508GSM8346507GSM8346506GSM834650518287270548Pseudomonas aeruginosa