{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE272nnn/GSE272917/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272917"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Targeting phosphodiesterase 8A (PDE8A) and adipogenesis to promote hair regeneration","description":"To maximally capture adipocytes and hair follicle keratinocytes, which are largely lost through enzymatic digestion in scRNA-seq, we performed single-nuclei RNA sequencing (Sn-RNAseq) of the developing mouse skin samples. The aim of this analysis was to identify key cell-cell interactions between adipocytes and hair follicle keratinocytes. Briefly, dorsal skin biopsies were collected from the developing C57BL/6 pups (at postnatal day 2) and 10x Genomics Sn-RNAseq was applied to identify distinct cell populations. After low quality nuclei and outliers were discarded, ～16481 nuclei were used for downstream bioinformatic analyses, including Unsupervised clustering, marker gene expression, and Cell-Chat signaling network analyses. Overall, our results reveal that adipocytes secrete growth factor to support hair follicle growth.","dates":{"publication":"2026/07/30"},"accession":"GSE272917","cross_references":{"GSM":["GSM8414849"],"GPL":["24247"],"GSE":["272917"],"taxon":["Mus musculus"]}}