{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE272nnn/GSE272954/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272954"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Blocking microglial reactivity via purinergic receptors prevents long-term cognitive deficits after transient ischemic attacks","description":"Our research introduces a novel animal model for transient ischemic attack (TIA), mimicking brief episodes without cell loss but resulting in long-term behavioral and neuronal deficits. We identified excessive microglial reactivity, driven by hyperacute ATP release, as a pivotal contributor to post-TIA neurological deficits, which was alleviated by inhibiting the P2Y12 receptor. This finding suggests that targeting microglial reactivity offers a promising strategy to prevent cognitive decline in TIA patients, opening avenues for further research in this under-explored area.","dates":{"publication":"2026/04/22"},"accession":"GSE272954","cross_references":{"GSM":["GSM8415530","GSM8415532","GSM8415531"],"GPL":["30172"],"GSE":["272954"],"taxon":["Mus musculus"],"PMID":["[41862768]"]}}