GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE272nnn/GSE272954/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE272954GEOGSEfalseBlocking microglial reactivity via purinergic receptors prevents long-term cognitive deficits after transient ischemic attacksOur research introduces a novel animal model for transient ischemic attack (TIA), mimicking brief episodes without cell loss but resulting in long-term behavioral and neuronal deficits. We identified excessive microglial reactivity, driven by hyperacute ATP release, as a pivotal contributor to post-TIA neurological deficits, which was alleviated by inhibiting the P2Y12 receptor. This finding suggests that targeting microglial reactivity offers a promising strategy to prevent cognitive decline in TIA patients, opening avenues for further research in this under-explored area.2026/04/22GSE272954GSM8415530GSM8415532GSM841553130172272954Mus musculus[41862768]