GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE274nnn/GSE274047/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274047GEOGSEfalseStudy of gene expression in mouse primary hepatocytes cultured in hydrogels with different stiffnesses in wild-type and YAP/TAZ knockout.Liver stiffness is extensively utilized as a crucial indicator in the diagnosis and monitoring of MASLD, the contribution of increased stiffness on impaired liver functions and its molecular mechanisms remains poorly understood. Wild-type or Yap/Taz knock-out hepatocytes were cultured on soft (1 kPa) and stiff (20 kPa) hydrogels to embody healthy and fibrotic livers and subjected to metabolomic and transcriptomic analyses.2026/05/15GSE274047GSM8442472GSM8442470GSM8442471GSM8442469GSM8442467GSM8442468GSM8442465GSM844246624247274047Mus musculus[41747066]