{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE274nnn/GSE274195/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274195"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"DREAMS Illuminates DNA & RNA Modification Landscapes with a Spotlight on TET1's New Role in m1A","description":"We developed DNA RNA Elements Areal Mass Spectrometry (DREAMS), a mass spectrometry imaging platform that spatially maps diverse nucleic acid modifications. Applying DREAMS to TET-deficient mouse brains, we uncover TET1’s unexpected role in regulating N1-methyladenosine (m1A), a pivotal RNA modification. While DREAMS reveals broad modification landscapes altered across TET knockouts, we establish TET1-m1A as a central regulatory node, revealing its regulation of neuronal activity-related transcripts and interplay with other modification-altering systems. Our work establishes DREAMS as a transformative tool for spatial epigenomics/epitranscriptomics and redefines TET enzymes as integrators of interconnected nucleic acid modification systems.","dates":{"publication":"2026/06/12"},"accession":"GSE274195","cross_references":{"GSM":["GSM8444929","GSM8444939","GSM8444938","GSM8444937","GSM8444936","GSM8444935","GSM8444934","GSM8444933","GSM8444932","GSM8444931","GSM8444930","GSM8444940"],"GPL":["24247"],"GSE":["274195"],"taxon":["Mus musculus"]}}