GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE274nnn/GSE274195/primaryOK200OtherMus musculusOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274195GEOGSEfalseDREAMS Illuminates DNA & RNA Modification Landscapes with a Spotlight on TET1's New Role in m1AWe developed DNA RNA Elements Areal Mass Spectrometry (DREAMS), a mass spectrometry imaging platform that spatially maps diverse nucleic acid modifications. Applying DREAMS to TET-deficient mouse brains, we uncover TET1’s unexpected role in regulating N1-methyladenosine (m1A), a pivotal RNA modification. While DREAMS reveals broad modification landscapes altered across TET knockouts, we establish TET1-m1A as a central regulatory node, revealing its regulation of neuronal activity-related transcripts and interplay with other modification-altering systems. Our work establishes DREAMS as a transformative tool for spatial epigenomics/epitranscriptomics and redefines TET enzymes as integrators of interconnected nucleic acid modification systems.2026/06/12GSE274195GSM8444929GSM8444939GSM8444938GSM8444937GSM8444936GSM8444935GSM8444934GSM8444933GSM8444932GSM8444931GSM8444930GSM844494024247274195Mus musculus