GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE274nnn/GSE274516/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274516GEOGSEfalseCombination of MEK and Autophagy Inhibition in the preclinical GEMM model of PDAC (KPC mice)In order to investigate the mechiansim of action and the effect of the combination of MEK/Autophagy Inhibition on pancreatic tumors, KPC mice were treated with Vehicle or combination of Trametinib and Hydroxychloroquine for 24 hours. PDAC tumors were collected and single cell suspension was subjected to single-cell RNA-Sequencing analysis.2026/06/17GSE274516GSM8450759GSM8450758GSM8450757GSM8450756GSM8450755GSM845075424247274516Mus musculus