{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE275nnn/GSE275204/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE275204"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transplantation-induced progenitor-like state determines successful hepatocyte engraftment","description":"Demonstrating safety and short-term efficacy in treating liver diseases, hepatocyte-based therapy still faces the challenge of limited engraftment of transplanted hepatocytes (Tx-Heps) in clinical settings, akin to issues encountered in cell therapy in other solid tissues. Here, we identified a conserved reprogramming state of Tx-Heps during engraftment, marked by the activation of liver progenitor genes and bipotential differentiation capacity. Associated with enhanced fitness, transplantation reprogramming of Tx-Heps is crucial for successful engraftment, as proven by transplantation failure upon hepatocyte-specific ablation of Arid1a, which is essential for Tx-Hep reprogramming. To validate translational potential, we artificially induced Tx-Hep reprogramming via either IL6 or IC7, a chimeric IL6 family protein, significantly enhancing engraftment of both murine and human hepatocytes. Our findings unveil early-stage cell fate reprogramming during transplantation and propose a promising strategy to augment hepatocyte engraftment, which might serve as an interesting framework to be studied in cell transplantation for other solid tissues.","dates":{"publication":"2026/08/18"},"accession":"GSE275204","cross_references":{"GSM":["GSM8472691"],"GPL":["24247"],"GSE":["275204"],"taxon":["Mus musculus"]}}