GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE275nnn/GSE275318/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE275318GEOGSEfalseEffect of GnRH administration on gene expression of obese mice neural stem cellsTo explore the underlying mechanism of recognitive enhancement after GnRH supplementation, we used an obese mouse model that was given high fat diet (HFD) for three months. Treatment with saline or GnRH was given via implanted osmotic pumps for one month. Treatment was started after two months of feeding. Our results revealed that GnRH significantly promoted hippocampal neurogenesis in obese mice via the GnRH receptor GnRHR, indicating the essential role of GnRH and its targets in hippocampal neural stem cells.2026/08/20GSE275318GSM8474670GSM8474671GSM8474667GSM8474666GSM8474669GSM847466824247275318Mus musculus