{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE275nnn/GSE275742/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE275742"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Cortex, hippocampus, striatum transcriptome analysis of Chd8 mutation (Asn2373LysfsX2) adult mice with C57BL/6J x 129/Sv background","description":"Autism spectrum disorders (ASD) are 4–5 times more common in males, possibly due to female protective effects (FPEs), which suggests females are less susceptible to ASD unless a genetic mutation is particularly strong. If this is the case, increasing the strength of a ASD-risk mutation above the female threshold may induce ASD symptoms both in females and males. To this end, we compared male and female phenotypes in heterozygous and homozygous mice carrying a patient-derived CHD8 mutation (Asn2373LysfsX2), using a hybrid genetic background to overcome homozygous lethality. Heterozygous Chd8+/N2373K males and females displayed sexually dimorphic phenotypes stronger than those in homozygous Chd8 N2373 /N2373K males and females in behaviors, brain blood flow, neuronal activity, synaptic transmission, and transcriptomes. These results suggest that a stronger Chd8 mutation suppresses sexual dimorphism in mice, supporting the FPE hypothesis in ASD.","dates":{"publication":"2026/09/17"},"accession":"GSE275742","cross_references":{"GSM":["GSM8483817","GSM8483738","GSM8483815","GSM8483739","GSM8483816","GSM8483813","GSM8483736","GSM8483737","GSM8483814","GSM8483778","GSM8483734","GSM8483811","GSM8483735","GSM8483779","GSM8483812","GSM8483787","GSM8483743","GSM8483744","GSM8483788","GSM8483741","GSM8483785","GSM8483742","GSM8483786","GSM8483783","GSM8483784","GSM8483740","GSM8483781","GSM8483782","GSM8483780","GSM8483749","GSM8483747","GSM8483748","GSM8483745","GSM8483789","GSM8483746","GSM8483754","GSM8483798","GSM8483799","GSM8483755","GSM8483796","GSM8483752","GSM8483797","GSM8483753","GSM8483750","GSM8483794","GSM8483751","GSM8483795","GSM8483792","GSM8483793","GSM8483790","GSM8483791","GSM8483758","GSM8483759","GSM8483756","GSM8483757","GSM8483765","GSM8483766","GSM8483763","GSM8483764","GSM8483761","GSM8483762","GSM8483760","GSM8483808","GSM8483809","GSM8483729","GSM8483806","GSM8483807","GSM8483804","GSM8483805","GSM8483728","GSM8483802","GSM8483769","GSM8483803","GSM8483767","GSM8483800","GSM8483801","GSM8483768","GSM8483776","GSM8483732","GSM8483810","GSM8483733","GSM8483777","GSM8483730","GSM8483774","GSM8483775","GSM8483731","GSM8483772","GSM8483773","GSM8483770","GSM8483771"],"GPL":["21103"],"GSE":["275742"],"taxon":["Mus musculus"],"PMID":["[42106518]"]}}