{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE275nnn/GSE275918/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE275918"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Whole brain transcriptome analysis of heterozygous and homozygous Chd8 mutation (Asn2373LysfsX2) mice age of P0, P25 and P56 with C57BL6/J x 129/Sv background","description":"Autism spectrum disorders (ASD) are 4–5 times more common in males, possibly due to female protective effects (FPEs), which suggests females are less susceptible to ASD unless a genetic mutation is particularly strong. If this is the case, increasing the strength of a ASD-risk mutation above the female threshold may induce ASD symptoms both in females and males. To this end, we compared male and female phenotypes in heterozygous and homozygous mice carrying a patient-derived CHD8 mutation (Asn2373LysfsX2), using a hybrid genetic background to overcome homozygous lethality. Heterozygous Chd8+/N2373K males and females displayed sexually dimorphic phenotypes stronger than those in homozygous Chd8 N2373 /N2373K males and females in behaviors, brain blood flow, neuronal activity, synaptic transmission, and transcriptomes. These results suggest that a stronger Chd8 mutation suppresses sexual dimorphism in mice, supporting the FPE hypothesis in ASD.","dates":{"publication":"2026/09/17"},"accession":"GSE275918","cross_references":{"GSM":["GSM8488075","GSM8488031","GSM8488030","GSM8488074","GSM8488033","GSM8488077","GSM8488076","GSM8488032","GSM8488035","GSM8488079","GSM8488078","GSM8488034","GSM8488037","GSM8488036","GSM8488039","GSM8488038","GSM8488071","GSM8488070","GSM8488073","GSM8488072","GSM8488042","GSM8488086","GSM8488041","GSM8488085","GSM8488044","GSM8488088","GSM8488087","GSM8488043","GSM8488046","GSM8488089","GSM8488045","GSM8488048","GSM8488047","GSM8488049","GSM8488080","GSM8488082","GSM8488081","GSM8488084","GSM8488040","GSM8488083","GSM8488053","GSM8488097","GSM8488052","GSM8488096","GSM8488055","GSM8488099","GSM8488098","GSM8488054","GSM8488057","GSM8488056","GSM8488059","GSM8488058","GSM8488019","GSM8488091","GSM8488090","GSM8488093","GSM8488092","GSM8488095","GSM8488051","GSM8488050","GSM8488094","GSM8488064","GSM8488020","GSM8488063","GSM8488022","GSM8488066","GSM8488021","GSM8488065","GSM8488024","GSM8488101","GSM8488068","GSM8488067","GSM8488100","GSM8488023","GSM8488026","GSM8488103","GSM8488102","GSM8488025","GSM8488069","GSM8488028","GSM8488105","GSM8488104","GSM8488027","GSM8488107","GSM8488029","GSM8488106","GSM8488108","GSM8488060","GSM8488062","GSM8488061"],"GPL":["21103"],"GSE":["275918"],"taxon":["Mus musculus"],"PMID":["[42106518]"]}}