{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE276nnn/GSE276033/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE276033"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Study on transcriptome changes of placenta in mice after subchronic exposure to polystyrene nanoplastics","description":"Nanoplastics, as an emerging persistent pollutant of global concern in recent years, have posed a potential threat to human health. However, there is little known about the adverse effects of nanoplastics on the female reproductive system. Here, polystyrene nanoplastics (PS-NPs) with a diameter of 50 nm were selected as representative nanosized plastic particles to investigate the potential effects of subchronic exposure on placenta development in mice. Maternal exposed to 10 mg/L PS-NPs via drinking water induced a significant increase in fetal weight. Further observation of the placental morphology showed that PS-NPs exposure caused aberrant placental structure and damaged trophoblast cells. At the cellular level, exposure to PS-NPs promoted the proliferation, migration and invasion ability of HTR-8/SVneo. Mechanistically, transcriptome and proteomic analysis reveal that PS-NPs triggered placental calcium disturbance and noticeably upregulated the STAM2 expression in mice. Importantly, STAM2 induced by PS-NPs mediates the imbalance of trophoblastic calcium homeostasis and regulates cell functions through disturbing calcium channel protein IP3R3 lysosome degradation in HTR-8/SVneo cells. Our results indicate that trophoblastic calcium dyshomeostasis is the main cause of abnormal placental development induced by PS-NPs subchronic exposure. These findings contribute to estimating the risk for PS-NPs on female reproductive and indicate a basis for prevention and treatment of placental impairment.","dates":{"publication":"2026/09/30"},"accession":"GSE276033","cross_references":{"GSM":["GSM8489860","GSM8489856","GSM8489855","GSM8489858","GSM8489857","GSM8489859"],"GPL":["17021"],"GSE":["276033"],"taxon":["Mus musculus"]}}