{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE276nnn/GSE276381/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Non-coding RNA profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE276381"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"microRNA profiling to identify the biological pathways potentially associated with the actions of IVIg treatment","description":"Purpose: Our study has demonstrated favorable effects of intravenous immunoglobin (IVIg) treatment on acute neurological status, motor function, anxiety level, and spatial learning ability after severe TBI in a controlled cortical impact (CCI) mouse model. We conducted high throughput small RNA-Seq to identify the biological pathways potentially associated with the actions of IVIg treatment. Methods: Differentially expressed (DE) miRNAs were identified using pairwise comparisons: a. TBI vs. sham, b. TBI-IVIg vs sham, and c. TBI vs TBI-IVIg (n =8 each treatment group), from brain samples and plasma samples collected 48 hours after TBI. Small RNAs were sequenced with 51 bp single-end reads using Illumina HiSeq 4000 and read quality was assessed using FastQC.","dates":{"publication":"2026/09/04"},"accession":"GSE276381","cross_references":{"GSM":["GSM8497449","GSM8497447","GSM8497469","GSM8497448","GSM8497467","GSM8497445","GSM8497468","GSM8497446","GSM8497465","GSM8497443","GSM8497444","GSM8497466","GSM8497441","GSM8497463","GSM8497464","GSM8497442","GSM8497461","GSM8497462","GSM8497440","GSM8497460","GSM8497438","GSM8497439","GSM8497436","GSM8497458","GSM8497437","GSM8497459","GSM8497434","GSM8497456","GSM8497457","GSM8497435","GSM8497476","GSM8497454","GSM8497432","GSM8497433","GSM8497477","GSM8497455","GSM8497430","GSM8497474","GSM8497452","GSM8497453","GSM8497431","GSM8497475","GSM8497450","GSM8497472","GSM8497473","GSM8497451","GSM8497470","GSM8497471"],"GPL":["21103"],"GSE":["276381"],"taxon":["Mus musculus"]}}