GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE276nnn/GSE276381/primaryOK200GenomicsMus musculusNon-coding RNA profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE276381GEOGSEfalsemicroRNA profiling to identify the biological pathways potentially associated with the actions of IVIg treatmentPurpose: Our study has demonstrated favorable effects of intravenous immunoglobin (IVIg) treatment on acute neurological status, motor function, anxiety level, and spatial learning ability after severe TBI in a controlled cortical impact (CCI) mouse model. We conducted high throughput small RNA-Seq to identify the biological pathways potentially associated with the actions of IVIg treatment. Methods: Differentially expressed (DE) miRNAs were identified using pairwise comparisons: a. TBI vs. sham, b. TBI-IVIg vs sham, and c. TBI vs TBI-IVIg (n =8 each treatment group), from brain samples and plasma samples collected 48 hours after TBI. Small RNAs were sequenced with 51 bp single-end reads using Illumina HiSeq 4000 and read quality was assessed using Fast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 musculus