{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE276nnn/GSE276755/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE276755"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Systemic and breast chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women (Human Bulk RNA-Seq)","description":"Estrogen receptor positive (ER+) breast cancer, the most common subtype of breast cancer, is an age-related disease, with the peak incidence of diagnosis occurring around age 70 despite low circulating levels of estradiol. Despite the hormone sensitivity of these age-related tumors, our understanding of the interplay between the systemic and local hormonal disposition and chronic inflammaging is limited. We show that aged F344 rats treated with the DMBA/MPA carcinogen develop more tumors at faster rates than their younger counterparts, suggesting that the aged environment accelerates tumor growth. snRNA-seq of the tumors showed broad local immune dysfunction that was associated with circulating chronic inflammation. Across a broad cohort of specimens from patients with ER+ breast cancer and age-matched donors of normal breast tissue, we observe that even with E1-predominant estrogen disposition in the systemic circulation, tumors in older patients upregulate HSD17B7 expression to convert E1 to E2 in the TME. Age-related accumulation of tumor-associated macrophages serve as signaling hubs that integrate the E2 and chemokine-driven chronic inflammatory signaling in the TME, which polarize TAMs towards a CD206+/PD-L1+, immunosuppressive phenotype. Overall, these findings suggest that the host’s chronic inflammation and hormonal disposition shape the local tumor microenvironment and are critical contributors to the age-related nature of ER+ breast cancer development and growth.","dates":{"publication":"2026/06/05"},"accession":"GSE276755","cross_references":{"GSM":["GSM8505336","GSM8505335","GSM8505334","GSM8505333","GSM8505339","GSM8505338","GSM8505337","GSM8505291","GSM8505290","GSM8505295","GSM8505294","GSM8505293","GSM8505292","GSM8505332","GSM8505299","GSM8505298","GSM8505331","GSM8505330","GSM8505297","GSM8505296","GSM8505347","GSM8505226","GSM8505346","GSM8505225","GSM8505224","GSM8505345","GSM8505344","GSM8505223","GSM8505229","GSM8505349","GSM8505228","GSM8505227","GSM8505348","GSM8505343","GSM8505222","GSM8505221","GSM8505342","GSM8505220","GSM8505341","GSM8505340","GSM8505314","GSM8505313","GSM8505279","GSM8505312","GSM8505311","GSM8505278","GSM8505318","GSM8505317","GSM8505316","GSM8505315","GSM8505319","GSM8505273","GSM8505272","GSM8505271","GSM8505270","GSM8505277","GSM8505310","GSM8505276","GSM8505275","GSM8505274","GSM8505325","GSM8505324","GSM8505323","GSM8505289","GSM8505322","GSM8505329","GSM8505328","GSM8505327","GSM8505326","GSM8505280","GSM8505284","GSM8505283","GSM8505282","GSM8505281","GSM8505321","GSM8505288","GSM8505320","GSM8505287","GSM8505286","GSM8505285","GSM8505259","GSM8505379","GSM8505258","GSM8505257","GSM8505378","GSM8505256","GSM8505377","GSM8505372","GSM8505251","GSM8505250","GSM8505371","GSM8505370","GSM8505376","GSM8505255","GSM8505375","GSM8505254","GSM8505253","GSM8505374","GSM8505373","GSM8505252","GSM8505303","GSM8505269","GSM8505302","GSM8505301","GSM8505268","GSM8505300","GSM8505267","GSM8505307","GSM8505306","GSM8505305","GSM8505304","GSM8505309","GSM8505308","GSM8505383","GSM8505262","GSM8505382","GSM8505261","GSM8505260","GSM8505381","GSM8505380","GSM8505266","GSM8505387","GSM8505386","GSM8505265","GSM8505264","GSM8505385","GSM8505263","GSM8505384","GSM8505237","GSM8505358","GSM8505236","GSM8505357","GSM8505356","GSM8505235","GSM8505234","GSM8505355","GSM8505239","GSM8505238","GSM8505359","GSM8505350","GSM8505233","GSM8505354","GSM8505353","GSM8505232","GSM8505352","GSM8505231","GSM8505230","GSM8505351","GSM8505369","GSM8505248","GSM8505247","GSM8505368","GSM8505246","GSM8505367","GSM8505366","GSM8505245","GSM8505249","GSM8505240","GSM8505361","GSM8505360","GSM8505244","GSM8505365","GSM8505243","GSM8505364","GSM8505363","GSM8505242","GSM8505241","GSM8505362"],"GPL":["24676"],"GSE":["276755"],"taxon":["Homo sapiens"]}}