{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE277nnn/GSE277135/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277135"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of tumour microenvironment landscape of mouse oral cancer tumours","description":"Access of CD8+ T cells inside tumour nests is shaped by the tumour microenvironment (TME). Cancer-associated fibroblasts (CAFs) are among the most abundant TME components and have been associated with poor survival and T cells exclusion. However, the mechanisms that link CAFs presence with T cell blockade are unclear and there is a huge unmet medical need to increase T cell accessibility inside tumour cores. Here, we established single cell RNAseq of syngeneic murine models of head and neck squamous cell carcinoma that recapitulate different tumour-stroma organizations and evolutions (MOC1 and MOC2). MOC1 tumours are immune indolent and transition from a T cell infiltrated to an immune excluded/desert TME over time. MOC2 are more aggressive and are rich in myeloid cells while being T cell desert.","dates":{"publication":"2026/09/01"},"accession":"GSE277135","cross_references":{"GSM":["GSM8514897","GSM8514896","GSM8514899","GSM8514898","GSM8514901","GSM8514900","GSM8514903","GSM8514902","GSM8514904"],"GPL":["24247"],"GSE":["277135"],"taxon":["Mus musculus"]}}