GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE277nnn/GSE277135/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277135GEOGSEfalseCharacterization of tumour microenvironment landscape of mouse oral cancer tumoursAccess of CD8+ T cells inside tumour nests is shaped by the tumour microenvironment (TME). Cancer-associated fibroblasts (CAFs) are among the most abundant TME components and have been associated with poor survival and T cells exclusion. However, the mechanisms that link CAFs presence with T cell blockade are unclear and there is a huge unmet medical need to increase T cell accessibility inside tumour cores. Here, we established single cell RNAseq of syngeneic murine models of head and neck squamous cell carcinoma that recapitulate different tumour-stroma organizations and evolutions (MOC1 and MOC2). MOC1 tumours are immune indolent and transition from a T cell infiltrated to an immune excluded/desert TME over time. MOC2 are more aggressive and are rich in myeloid cells while being T cell desert.2026/09/01GSE277135GSM8514897GSM8514896GSM8514899GSM8514898GSM8514901GSM8514900GSM8514903GSM8514902GSM851490424247277135Mus musculus