{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE277nnn/GSE277411/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":[" synthetic construct","Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277411"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Gene identification for ocular congenital cranial motor neuron disorders using human sequencing, zebrafish screening, and protein binding microarrays","description":"Through exome and genome sequencing of a genetically unsolved human oCCDD cohort, we previously identified variants in 80 strong candidate genes. Here, we further prioritized a subset of these (43 human genes, 57 zebrafish genes) using a G0 CRISPR/Cas9-based knockout assay in zebrafish and generated F2 germline mutants for seventeen. We tested the functionality of variants of uncertain significance in known and novel candidate transcription factor-encoding genes through protein binding microarrays.","dates":{"publication":"2026/08/10"},"accession":"GSE277411","cross_references":{"GSM":["GSM8521902","GSM8521903","GSM8521900","GSM8521901","GSM8521898","GSM8521899","GSM8521896","GSM8521897","GSM8521894","GSM8521895","GSM8521904","GSM8521905"],"GPL":["33450"],"GSE":["277411"],"taxon":[" synthetic construct","Homo sapiens"],"PMID":["[40162949]"]}}