GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE277nnn/GSE277411/primaryOK200Genomics synthetic constructHomo sapiensGenome binding/occupancy profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277411GEOGSEfalseGene identification for ocular congenital cranial motor neuron disorders using human sequencing, zebrafish screening, and protein binding microarraysThrough exome and genome sequencing of a genetically unsolved human oCCDD cohort, we previously identified variants in 80 strong candidate genes. Here, we further prioritized a subset of these (43 human genes, 57 zebrafish genes) using a G0 CRISPR/Cas9-based knockout assay in zebrafish and generated F2 germline mutants for seventeen. We tested the functionality of variants of uncertain significance in known and novel candidate transcription factor-encoding genes through protein binding microarrays.2026/08/10GSE277411GSM8521902GSM8521903GSM8521900GSM8521901GSM8521898GSM8521899GSM8521896GSM8521897GSM8521894GSM8521895GSM8521904GSM852190533450277411 synthetic constructHomo sapiens[40162949]