{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE277nnn/GSE277496/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277496"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell multiomics of peripheral blood monocytes in Crohn's Disease","description":"Dysfunctional intestinal monocyte-derived macrophages contribute to pathology in Inflammatory Bowel Disease (IBD). Signals from the tissue micro-environment contribute to this dysfunction, however growing evidence suggests that monocytes can be primed for inflammatory function prior to tissue recruitment. Here we use single-nucleus multiomics, comprising RNA sequencing (RNA-seq) and assay for transposase-accessible chromatin using sequencing (ATAC-seq) to identify regulatory elements underlying the altered transcriptional profile in monocytes from newly diagnosed, treatment naive Crohn’s disease patients.","dates":{"publication":"2026/07/23"},"accession":"GSE277496","cross_references":{"GSM":["GSM8523383","GSM8523382","GSM8523381","GSM8523380","GSM8523379","GSM8523378","GSM8523377","GSM8523387","GSM8523376","GSM8523386","GSM8523385","GSM8523384"],"GPL":["30173"],"GSE":["277496"],"taxon":["Homo sapiens"]}}