GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE277nnn/GSE277496/primaryOK200TranscriptomicsHomo sapiens Genome binding/occupancy profiling by high throughput sequencingExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277496GEOGSEfalseSingle-cell multiomics of peripheral blood monocytes in Crohn's DiseaseDysfunctional intestinal monocyte-derived macrophages contribute to pathology in Inflammatory Bowel Disease (IBD). Signals from the tissue micro-environment contribute to this dysfunction, however growing evidence suggests that monocytes can be primed for inflammatory function prior to tissue recruitment. Here we use single-nucleus multiomics, comprising RNA sequencing (RNA-seq) and assay for transposase-accessible chromatin using sequencing (ATAC-seq) to identify regulatory elements underlying the altered transcriptional profile in monocytes from newly diagnosed, treatment naive Crohn’s disease patients.2026/07/23GSE277496GSM8523383GSM8523382GSM8523381GSM8523380GSM8523379GSM8523378GSM8523377GSM8523387GSM8523376GSM8523386GSM8523385GSM852338430173277496Homo sapiens