{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE277nnn/GSE277610/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277610"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Endothelial PD-L1 brakes CD8+ T cell exhaustion, empowering anti-tumor immunity in non-small cell lung cancer","description":"Cancer immunotherapies targeting PD-(L)1 offer therapeutic potential but suffer resistance. The role of PD-L1 in tumor and myeloid cells has been extensively studied, while its function in tumor endothelial cells (ECs) is overlooked. Surprisingly, we identified an unknown role of EC-specific PD-L1 in delaying the exhaustion of tumor-infiltrating CD8+ T cells in a non-small cell lung cancer mouse model. Loss of endothelial PD-L1 reduces T cell activation and exac-erbates tumor growth. Initial inhibition of CD8+ T cells by endothelial PD-L1, prior to encoun-tering cancer cells, prevents T cells from prematurely reaching a terminal exhaustion state. Initial results suggest that high EC PD-L1 expression in NSCLC patient tumors might become a potential positive predictor of anti-PD-1 outcome. These unexpected findings highlight the significance of vessel-associated PD-L1 and suggest that EC PD-L1 blockade upon systemic treatment potentially negates the overall therapeutic effect, raising the question if this might contribute to therapy resistance.","dates":{"publication":"2026/06/01"},"accession":"GSE277610","cross_references":{"GSM":["GSM8526310","GSM8526311","GSM8526312","GSM8526313","GSM8526314","GSM8526304","GSM8526315","GSM8526305","GSM8526316","GSM8526317","GSM8526306","GSM8526318","GSM8526307","GSM8526308","GSM8526319","GSM8526309","GSM8526320"],"GPL":["24247"],"GSE":["277610"],"taxon":["Mus musculus"]}}