{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE277nnn/GSE277860/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by genome tiling array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277860"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Association of Epigenetic Trajectory With Development of Clinical Rheumatoid Arthritis in Individuals With Anti–Citrullinated Protein Antibody Positivity: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA)","description":"The presence of autoantibodies to citrullinated protein antigens (ACPAs) in the absence of clinically-apparent inflammatory arthritis (IA) identifies individuals “at-risk” for developing future clinical rheumatoid arthritis (RA). However, it is unclear why some ACPA+ individuals convert to clinical RA while others do not. We explored the possibility in the Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA) study that epigenetic remodeling is part of the trajectory from an at-risk state to clinical disease and identifies novel biomarkers associated with conversion to clinical RA.","dates":{"publication":"2026/09/01"},"accession":"GSE277860","cross_references":{"GSM":["GSM8532955","GSM8532834","GSM8532835","GSM8532956","GSM8532836","GSM8532957","GSM8532958","GSM8532837","GSM8532951","GSM8532830","GSM8532831","GSM8532952","GSM8532953","GSM8532832","GSM8532833","GSM8532954","GSM8532950","GSM8532827","GSM8532948","GSM8532828","GSM8532949","GSM8532829","GSM8532944","GSM8532823","GSM8532824","GSM8532945","GSM8532825","GSM8532946","GSM8532947","GSM8532826","GSM8532940","GSM8532941","GSM8532820","GSM8532821","GSM8532942","GSM8532822","GSM8532943","GSM8532816","GSM8532937","GSM8532938","GSM8532817","GSM8532818","GSM8532939","GSM8532819","GSM8532812","GSM8532933","GSM8532813","GSM8532934","GSM8532935","GSM8532814","GSM8532815","GSM8532936","GSM8532930","GSM8532810","GSM8532931","GSM8532932","GSM8532811","GSM8532809","GSM8532926","GSM8532805","GSM8532927","GSM8532806","GSM8532807","GSM8532928","GSM8532929","GSM8532808","GSM8532801","GSM8532922","GSM8532802","GSM8532923","GSM8532924","GSM8532803","GSM8532804","GSM8532925","GSM8532920","GSM8532921","GSM8532800","GSM8532919","GSM8532915","GSM8532916","GSM8532917","GSM8532918","GSM8532911","GSM8532912","GSM8532913","GSM8532914","GSM8532910","GSM8532908","GSM8532909","GSM8532904","GSM8532905","GSM8532906","GSM8532907","GSM8532900","GSM8532901","GSM8532902","GSM8532903","GSM8533098","GSM8533097","GSM8533099","GSM8533094","GSM8533093","GSM8533096","GSM8533095","GSM8533090","GSM8533092","GSM8533091","GSM8533407","GSM8533406","GSM8533409","GSM8533408","GSM8533403","GSM8532797","GSM8532798","GSM8533402","GSM8533405","GSM8532799","GSM8533404","GSM8533401","GSM8533400","GSM8532796","GSM8533517","GSM8533516","GSM8533518","GSM8533513","GSM8533512","GSM8533515","GSM8533514","GSM8533511","GSM8533510","GSM8533509","GSM8533506","GSM8533505","GSM8533508","GSM8533507","GSM8533502","GSM8532896","GSM8533501","GSM8532897","GSM8532898","GSM8533504","GSM8532899","GSM8533503","GSM8532892","GSM8532893","GSM8533500","GSM8532894","GSM8532895","GSM8532890","GSM8532891","GSM8532889","GSM8532885","GSM8532886","GSM8532887","GSM8532888","GSM8532881","GSM8532882","GSM8532883","GSM8532884","GSM8532880","GSM8532878","GSM8532999","GSM8532879","GSM8532874","GSM8532995","GSM8532996","GSM8532875","GSM8532876","GSM8532997","GSM8532877","GSM8532998","GSM8532870","GSM8532991","GSM8532871","GSM8532992","GSM8532993","GSM8532872","GSM8532873","GSM8532994","GSM8532990","GSM8532867","GSM8532988","GSM8532868","GSM8532989","GSM8532869","GSM8532984","GSM8532863","GSM8532864","GSM8532985","GSM8532865","GSM8532986","GSM8532987","GSM8532866","GSM8532980","GSM8532981","GSM8532860","GSM8532861","GSM8532982","GSM8532862","GSM8532983","GSM8532977","GSM8532856","GSM8532857","GSM8532978","GSM8532858","GSM8532979","GSM8532859","GSM8532973","GSM8532852","GSM8532974","GSM8532853","GSM8532854","GSM8532975","GSM8532855","GSM8532976","GSM8532970","GSM8532971","GSM8532850","GSM8532851","GSM8532972","GSM8532849","GSM8532845","GSM8532966","GSM8532967","GSM8532846","GSM8532847","GSM8532968","GSM8532848","GSM8532969","GSM8532841","GSM8532962","GSM8532842","GSM8532963","GSM8532964","GSM8532843","GSM8532844","GSM8532965","GSM8532960","GSM8532961","GSM8532840","GSM8532838","GSM8532959","GSM8532839","GSM8533128","GSM8533007","GSM8533249","GSM8533127","GSM8533369","GSM8533248","GSM8533006","GSM8533009","GSM8533008","GSM8533129","GSM8533003","GSM8533366","GSM8533487","GSM8533245","GSM8533124","GSM8533365","GSM8533002","GSM8533486","GSM8533244","GSM8533123","GSM8533368","GSM8533005","GSM8533489","GSM8533247","GSM8533126","GSM8533488","GSM8533125","GSM8533004","GSM8533246","GSM8533367","GSM8533362","GSM8533483","GSM8533120","GSM8533241","GSM8533482","GSM8533240","GSM8533361","GSM8533485","GSM8533001","GSM8533122","GSM8533243","GSM8533364","GSM8533242","GSM8533363","GSM8533000","GSM8533484","GSM8533121","GSM8533360","GSM8533481","GSM8533480","GSM8533359","GSM8533117","GSM8533238","GSM8533479","GSM8533116","GSM8533237","GSM8533358","GSM8533119","GSM8533239","GSM8533118","GSM8533113","GSM8533234","GSM8533355","GSM8533476","GSM8533233","GSM8533354","GSM8533475","GSM8533112","GSM8533236","GSM8533357","GSM8533478","GSM8533115","GSM8533114","GSM8533356","GSM8533477","GSM8533235","GSM8533230","GSM8533472","GSM8533351","GSM8533471","GSM8533350","GSM8533111","GSM8533474","GSM8533353","GSM8533232","GSM8533110","GSM8533231","GSM8533352","GSM8533473","GSM8533470","GSM8533109","GSM8533348","GSM8533106","GSM8533469","GSM8533227","GSM8533468","GSM8533105","GSM8533347","GSM8533226","GSM8533108","GSM8533229","GSM8533228","GSM8533107","GSM8533349","GSM8533465","GSM8533102","GSM8533223","GSM8533344","GSM8533222","GSM8533343","GSM8533101","GSM8533464","GSM8533225","GSM8533104","GSM8533346","GSM8533467","GSM8533345","GSM8533466","GSM8533103","GSM8533224","GSM8533340","GSM8533461","GSM8533460","GSM8533342","GSM8533463","GSM8533221","GSM8533100","GSM8533462","GSM8533220","GSM8533341","GSM8533219","GSM8533216","GSM8533337","GSM8533458","GSM85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