GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE277nnn/GSE277860/primaryOK200Methylation profilingHomo sapiensMethylation profiling by genome tiling arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277860GEOGSEfalseAssociation of Epigenetic Trajectory With Development of Clinical Rheumatoid Arthritis in Individuals With Anti–Citrullinated Protein Antibody Positivity: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA)The presence of autoantibodies to citrullinated protein antigens (ACPAs) in the absence of clinically-apparent inflammatory arthritis (IA) identifies individuals “at-risk” for developing future clinical rheumatoid arthritis (RA). However, it is unclear why some ACPA+ individuals convert to clinical RA while others do not. We explored the possibility in the Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA) study that epigenetic remodeling is part of the trajectory from an at-risk state to clinical disease and identifies novel biomarkers associated with conversion to clinical RA.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sapiens[42021528]