{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE278nnn/GSE278368/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE278368"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Differences of gene expression in liver of WT mice, Con A mice and FMT-Con A mice","description":"Clinical data have shown that decreased diversity and total number of gut microbiotas are associated with an increased prevalence of AIH. The gut microbiota serves as a critical link between the external environment and our internal environment, with an inseparable bidirectional relationship between the liver and the gut. Previous research has uncovered a fascinating phenomenon: AIH model mice induced with Con A exhibit a remarkably strong self-healing ability within 48 hours. Focusing on the post-Con A treatment timepoint. To investigate the effects of fecal microbiota transplantation (FMT) on Con A-induced AIH, we transplanted microbiota from Con A donor mice into recipient mice for 4 weeks prior to Con A challenge. FMT-Con A recipient mice liver showed significantly improve post-Con A treatment, compared to Con A-only mice.","dates":{"publication":"2026/05/19"},"accession":"GSE278368","cross_references":{"GSM":["GSM8545418","GSM8545419","GSM8545414","GSM8545415","GSM8545416","GSM8545417","GSM8545421","GSM8545422","GSM8545420"],"GPL":["13112"],"GSE":["278368"],"taxon":["Mus musculus"]}}