GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE278nnn/GSE278368/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE278368GEOGSEfalseDifferences of gene expression in liver of WT mice, Con A mice and FMT-Con A miceClinical data have shown that decreased diversity and total number of gut microbiotas are associated with an increased prevalence of AIH. The gut microbiota serves as a critical link between the external environment and our internal environment, with an inseparable bidirectional relationship between the liver and the gut. Previous research has uncovered a fascinating phenomenon: AIH model mice induced with Con A exhibit a remarkably strong self-healing ability within 48 hours. Focusing on the post-Con A treatment timepoint. To investigate the effects of fecal microbiota transplantation (FMT) on Con A-induced AIH, we transplanted microbiota from Con A donor mice into recipient mice for 4 weeks prior to Con A challenge. FMT-Con A recipient mice liver showed significantly improve post-Con A treatment, compared to Con A-only mice.2026/05/19GSE278368GSM8545418GSM8545419GSM8545414GSM8545415GSM8545416GSM8545417GSM8545421GSM8545422GSM854542013112278368Mus musculus