{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE278nnn/GSE278556/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE278556"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Mechanosensing by T cells promotes a tissue-resident memory transcriptional program","description":"Cell migration and strategic positioning within tissues is critical for the rapid mobilization of a T cell response. T cells must remain motile in both lymphoid and non-lymphoid tissues, which vary widely in mechanical properties such as stiffness. Here we showed that activated T cells sensed mechanical cues and responded with changes in cell morphology, nuclear envelope composition and initiation of DNA repair to protect their genomic material from force-mediated damage. Increased mechanical input also drove the transcriptional reprogramming of activated T cells, including changes in many of the core genes shared by tissue resident memory T (TRM) cells across diverse tissues, by modulating the expression of the TRM cell-associated transcription factors Klf2, Runx3 and Hic1. Thus, mechanosensing by activated T cells impacted T cell fate, promoting a transcriptional program associated with tissue-residency.","dates":{"publication":"2026/06/02"},"accession":"GSE278556","cross_references":{"GSM":["GSM8548807","GSM8548806","GSM8548809","GSM8548808","GSM8548814","GSM8548813","GSM8548805","GSM8548816","GSM8548815","GSM8548810","GSM8548812","GSM8548811"],"GPL":["24247"],"GSE":["278556"],"taxon":["Mus musculus"]}}