{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE278nnn/GSE278661/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE278661"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Adipogenesis of human mesenteric tissue","description":"Creeping fat (CrF), defined as the hyperplasia of mesenteric adipose tissue surrounding inflamed intestinal segments, is a characteristic pathological feature of Crohn’s disease and is associated with disease progression and postoperative recurrence. To investigate the cellular composition and transcriptional alterations underlying CrF formation, we generated a single-nucleus RNA sequencing atlas of human mesenteric tissues from patients with Crohn’s disease and healthy controls. This dataset includes intestinal creeping fat (ICF) and corresponding intestinal non-inflamed fat (INF) from patients with Crohn’s disease, as well as normal mesenteric tissue (NL) from healthy controls. The data were used to characterize disease-associated changes in mesenteric tissue cell populations and to explore potential cellular and molecular mechanisms involved in CrF formation.","dates":{"publication":"2026/06/12"},"accession":"GSE278661","cross_references":{"GSM":["GSM9812231","GSM9812230","GSM9812226","GSM9812237","GSM9812236","GSM9812225","GSM9812228","GSM9812238","GSM9812227","GSM9812233","GSM9812232","GSM9812235","GSM9812234","GSM8552409","GSM9812229"],"GPL":["24676"],"GSE":["278661"],"taxon":["Homo sapiens"]}}