GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE278nnn/GSE278661/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE278661GEOGSEfalseAdipogenesis of human mesenteric tissueCreeping fat (CrF), defined as the hyperplasia of mesenteric adipose tissue surrounding inflamed intestinal segments, is a characteristic pathological feature of Crohn’s disease and is associated with disease progression and postoperative recurrence. To investigate the cellular composition and transcriptional alterations underlying CrF formation, we generated a single-nucleus RNA sequencing atlas of human mesenteric tissues from patients with Crohn’s disease and healthy controls. This dataset includes intestinal creeping fat (ICF) and corresponding intestinal non-inflamed fat (INF) from patients with Crohn’s disease, as well as normal mesenteric tissue (NL) from healthy controls. The data were used to characterize disease-associated changes in mesenteric tissue cell populations and to explore potential cellular and molecular mechanisms involved in CrF formation.2026/06/12GSE278661GSM9812231GSM9812230GSM9812226GSM9812237GSM9812236GSM9812225GSM9812228GSM9812238GSM9812227GSM9812233GSM9812232GSM9812235GSM9812234GSM8552409GSM981222924676278661Homo sapiens