GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279194/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279194GEOGSEfalsePlacental transcriptome and autismHere, using a nested case-cohort design within an Australian population-derived prebirth cohort study (n=1074), we assessed the differential expression of genes and pathways in the placenta, comparing 43 children with a paediatrician-confirmed diagnosis of autism using DSM-5 criteria with a random sample of 120 participants without autism. We identified 1,644 differentially expressed genes (DEGs; FDR<0.05) in the placenta of children with autism compared to the control sub-cohort. The top enriched pathways related to mitochondrial function, oxidative stress and ribosomal pathways. CYP1A1, the most important xenobiotic-metabolising enzyme of the placenta, was the top downregulated DEG in the placenta of children with autism, while immuno-regulatory human leukocyte antigen (HLA)-related genes were among the top upregulated DEGs. We also used sparse partial least squares discriminant analysis to predict autism from the transcriptomic data. This approach resulted in a median sensitivity of 0.57 and median specificity of 0.92 for predicting subsequent autism diagnosis.2026/08/31GSE279194GSM8564036GSM8563981GSM8563980GSM8564035GSM8564034GSM8564033GSM8564032GSM8564031GSM8564030GSM8563989GSM8563988GSM8563987GSM8563986GSM8563985GSM8563984GSM8564039GSM8563983GSM8564038GSM8563982GSM8564037GSM8564025GSM8564024GSM8564023GSM8564022GSM8564021GSM8564020GSM8564140GSM8564141GSM8564142GSM8564029GSM8564028GSM8564027GSM8564026GSM8564050GSM8564058GSM8564057GSM8564056GSM8564055GSM8564054GSM8564053GSM8564052GSM8564051GSM8564059GSM8564047GSM8563992GSM8564046GSM8563991GSM8563990GSM8564045GSM8564044GSM8564043GSM8564042GSM8564041GSM8564040GSM8563999GSM8563998GSM8563997GSM8563996GSM8563995GSM8563994GSM8564049GSM8563993GSM8564048GSM8564072GSM8564071GSM8564070GSM8564114GSM8564079GSM8564115GSM8564116GSM8564078GSM8564117GSM8564077GSM8564076GSM8564118GSM8564119GSM8564075GSM8564074GSM8564073GSM8564110GSM8564111GSM8564112GSM8564113GSM8564061GSM8564060GSM8564103GSM8564069GSM8564104GSM8564068GSM8564067GSM8564105GSM8564066GSM8564106GSM8564107GSM8564065GSM8564064GSM8564108GSM8564063GSM8564109GSM8564062GSM8564100GSM8564101GSM8564102GSM8564094GSM8564093GSM8564092GSM8564091GSM8564090GSM8564136GSM8564014GSM8564013GSM8564137GSM8564012GSM8564138GSM8564139GSM8564011GSM8564099GSM8564010GSM8564098GSM8564097GSM8564096GSM8564095GSM8564130GSM8564131GSM8564019GSM8564018GSM8564132GSM8564133GSM8564017GSM8564134GSM8564016GSM8564015GSM8564135GSM8564083GSM8564082GSM8564081GSM8564080GSM8564125GSM8564003GSM8564002GSM8564126GSM8564001GSM8564127GSM8564089GSM8564088GSM8564000GSM8564128GSM8564087GSM8564129GSM8564086GSM8564085GSM8564084GSM8564009GSM8564008GSM8564120GSM8564007GSM8564121GSM8564122GSM8564006GSM8564005GSM8564123GSM8564004GSM856412424676279194Homo sapiens