GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279407/primaryOK200GenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279407GEOGSEfalseChromatin accessibility profiles of activated hematopoietic stem cells under several conditions [ATAC-Seq]Self-renewing hematopoietic stem cells (HSCs) during hematopoietic regeneration showed lower intracellular glutamate (Glu) levels compared with dividing progenitor cells in the steady state and HSCs that attenuate stem cell features during ex vivo culture. Moreover, R162, an inhibitor of glutamine dehydrogenase (Glud1) that catabolize Glu into α-ketoglutarate, contributed to stem cell maintenance during HSC divisions. These data suggest that lower intracellular Glu levels during HSC division contributed to self-renewing divisions by suppressing Glud1-mediated reactions.2026/07/13GSE279407GSM8569450GSM8569451GSM8569449GSM8569443GSM8569454GSM8569455GSM8569444GSM8569452GSM8569442GSM8569453GSM8569458GSM8569447GSM8569448GSM8569445GSM8569456GSM8569457GSM856944621273279407Mus musculus