{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279594/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":[" Mus musculus","Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279594"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"BCR::ABL1-induced enhancer reprogramming uncovers hypersensitivity of Ph+B-ALL cells to enhancer-targeting drugs [RNA-Seq]","description":"To better understand how BCR::ABL1 establishes the Ph+B-ALL-defining transcriptional program, we adopted an integrative multi-omics approach to study the transcriptome, enhancer activities, and 3-dimensional interactions of enhancers with target genes in Ph+B-ALL cells. We performed an in-depth analysis of cells from human Ph+B-ALL patients and a murine Ph+B-ALL model using ChIP-Seq, RNA-Seq, and Hi-C-based methods to link enhancers to the promoters they regulate.","dates":{"publication":"2026/02/27"},"accession":"GSE279594","cross_references":{"GSM":["GSM9448029","GSM9448028","GSM8576642","GSM8576641","GSM8576640","GSM8576646","GSM8576645","GSM8576644","GSM8576643","GSM9448051","GSM9448050","GSM8576631","GSM8576630","GSM8576639","GSM8576638","GSM9448049","GSM8576637","GSM9448048","GSM8576636","GSM8576635","GSM9448047","GSM9448046","GSM8576634","GSM9448045","GSM8576633","GSM8576632","GSM9448044","GSM9448043","GSM9448042","GSM9448041","GSM9448040","GSM8576629","GSM8576620","GSM8576628","GSM8576627","GSM9448039","GSM8576626","GSM9448038","GSM9448037","GSM8576625","GSM8576624","GSM9448036","GSM8576623","GSM9448035","GSM9448034","GSM8576622","GSM8576621","GSM9448033","GSM9448032","GSM9448031","GSM9448030","GSM8576619"],"GPL":["20301","21103"],"GSE":["279594"],"taxon":[" Mus musculus","Homo sapiens"]}}