GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279594/primaryOK200Transcriptomics Mus musculusHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279594GEOGSEfalseBCR::ABL1-induced enhancer reprogramming uncovers hypersensitivity of Ph+B-ALL cells to enhancer-targeting drugs [RNA-Seq]To better understand how BCR::ABL1 establishes the Ph+B-ALL-defining transcriptional program, we adopted an integrative multi-omics approach to study the transcriptome, enhancer activities, and 3-dimensional interactions of enhancers with target genes in Ph+B-ALL cells. We performed an in-depth analysis of cells from human Ph+B-ALL patients and a murine Ph+B-ALL model using ChIP-Seq, RNA-Seq, and Hi-C-based methods to link enhancers to the promoters they regulate.2026/02/27GSE279594GSM9448029GSM9448028GSM8576642GSM8576641GSM8576640GSM8576646GSM8576645GSM8576644GSM8576643GSM9448051GSM9448050GSM8576631GSM8576630GSM8576639GSM8576638GSM9448049GSM8576637GSM9448048GSM8576636GSM8576635GSM9448047GSM9448046GSM8576634GSM9448045GSM8576633GSM8576632GSM9448044GSM9448043GSM9448042GSM9448041GSM9448040GSM8576629GSM8576620GSM8576628GSM8576627GSM9448039GSM8576626GSM9448038GSM9448037GSM8576625GSM8576624GSM9448036GSM8576623GSM9448035GSM9448034GSM8576622GSM8576621GSM9448033GSM9448032GSM9448031GSM9448030GSM85766192030121103279594 Mus musculusHomo sapiens