{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279644/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":[" Mus musculus","Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279644"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"BCR::ABL1-induced enhancer reprogramming uncovers hypersensitivity of Ph+B-ALL cells to enhancer-targeting drugs [ChIP-Seq]","description":"To better understand how BCR::ABL1 establishes the Ph+B-ALL-defining transcriptional program, we adopted an integrative multi-omics approach to study the transcriptome, enhancer activities, and 3-dimensional interactions of enhancers with target genes in Ph+B-ALL cells. We performed an in-depth analysis of cells from human Ph+B-ALL patients and a murine Ph+B-ALL model using ChIP-Seq, RNA-Seq, and Hi-C-based methods to link enhancers to the promoters they regulate. We further interfered with enhancer function to explore their role in Ph+B-ALL and investigated BCR::ABL1-regulated TFs that are recruited to them using targeted proteasomal degradation and RNA interference (RNAi).","dates":{"publication":"2026/02/27"},"accession":"GSE279644","cross_references":{"GSM":["GSM8577423","GSM9037548","GSM8577422","GSM8577389","GSM8577388","GSM9447979","GSM8577421","GSM8577420","GSM8577387","GSM9037549","GSM9447977","GSM9037544","GSM8577386","GSM8577385","GSM9447978","GSM9037543","GSM9447975","GSM8577384","GSM8577383","GSM9037545","GSM9447976","GSM9037540","GSM9447973","GSM9447974","GSM9447971","GSM9037542","GSM9037541","GSM9447972","GSM8577427","GSM8577426","GSM9447970","GSM8577425","GSM8577424","GSM8577382","GSM8577381","GSM8577380","GSM8577379","GSM8577412","GSM8577411","GSM8577378","GSM9447968","GSM8577410","GSM9447969","GSM9447966","GSM9037555","GSM9037554","GSM9447967","GSM9447964","GSM9447965","GSM9447962","GSM9037551","GSM9037550","GSM8577419","GSM9447963","GSM9037553","GSM8577418","GSM8577417","GSM9447961","GSM9037552","GSM8577416","GSM8577415","GSM8577414","GSM8577413","GSM8577409","GSM9037537","GSM9037536","GSM8577399","GSM9037539","GSM9037538","GSM8577398","GSM9447988","GSM8577397","GSM9037533","GSM8577396","GSM9447989","GSM9447986","GSM8577395","GSM9037535","GSM8577394","GSM9447987","GSM9037534","GSM9447984","GSM9447985","GSM9447982","GSM9447983","GSM9447980","GSM9447981","GSM8577393","GSM8577392","GSM8577391","GSM8577390"],"GPL":["20301","21103"],"GSE":["279644"],"taxon":[" Mus musculus","Homo sapiens"]}}