GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279644/primaryOK200Genomics Mus musculusHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279644GEOGSEfalseBCR::ABL1-induced enhancer reprogramming uncovers hypersensitivity of Ph+B-ALL cells to enhancer-targeting drugs [ChIP-Seq]To better understand how BCR::ABL1 establishes the Ph+B-ALL-defining transcriptional program, we adopted an integrative multi-omics approach to study the transcriptome, enhancer activities, and 3-dimensional interactions of enhancers with target genes in Ph+B-ALL cells. We performed an in-depth analysis of cells from human Ph+B-ALL patients and a murine Ph+B-ALL model using ChIP-Seq, RNA-Seq, and Hi-C-based methods to link enhancers to the promoters they regulate. We further interfered with enhancer function to explore their role in Ph+B-ALL and investigated BCR::ABL1-regulated TFs that are recruited to them using targeted proteasomal degradation and RNA interference (RNAi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us musculusHomo sapiens