GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE27nnn/GSE27978/primaryOK2000000GenomicsRattus norvegicusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27978GEOGSE0falseIL-6-mediated activation of STAT3α prevents trauma/hemorrhagic shock-induced liver inflammationWe previously demonstrated in rodents that T/HS results in liver injury that can be prevented by IL-6 administration at the start of resuscitation, however the mechanism(s) for the IL-6 protective effect is not fully known. We used microarrays to detail the global gene expression in response to T/HS and the effect of IL-6 on this model with and without pharmacologic blockade of Stat3-mediated IL-6 and identified distinct members of the inflammasome de-regulated during T/HS that normalized with IL-6 administration during resuscitation.2011/03/16GSE27978GSM692406GSM692407GSM692408GSM692409GSM692402GSM692403GSM692404GSM692405GSM692398GSM692399GSM692400GSM692401GSM692395GSM692396GSM69239734127978Rattus norvegicus