{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE280nnn/GSE280827/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE280827"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"ChIP-seq of H3K27ac and H3K27me3 in the hippocampus of C57BL/6 mice after high methionine feeding for more than 8 weeks.","description":"To explore whether high homocysteine status affects the enrichment of histone H3K27ac and H3K27me3 and thus affects the cognitive behavioral abilities of mice, we fed C57BL/6 mice with a high-methionine diet and a standard diet, then isolated the hippocampus for ChIP-seq studies of H3K27ac and H3K27me3. The sequencing data provided a new theoretical basis for the effects of high homocysteine on histone modification.","dates":{"publication":"2026/08/12"},"accession":"GSE280827","cross_references":{"GSM":["GSM8606262","GSM8606261","GSM8606257","GSM8606259","GSM8606258","GSM8606260"],"GPL":["24247"],"GSE":["280827"],"taxon":["Mus musculus"],"PMID":["[40903958]"]}}