{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE280nnn/GSE280925/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE280925"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"ZCCHC10 promotes RBM39 degradation to suppress RBM39-mediated mis-splicing in acute myeloid leukemia","description":"Our previous studies have shown that CCHC-type zinc finger containing 10 (ZCCHC10) plays a tumor suppressive role in acute myeloid leukemia (AML) and lung cancer by activating the tumor suppressor p53. Here we report that ZCCHC10 promotes PSME3-mediated degradation of RBM39，thereby regulating transcription and mRNA splicing.","dates":{"publication":"2026/08/21"},"accession":"GSE280925","cross_references":{"GSM":["GSM8607571","GSM8607560","GSM8607570","GSM8607562","GSM8607573","GSM8607561","GSM8607572","GSM8607564","GSM8607575","GSM8607553","GSM8607574","GSM8607563","GSM8607566","GSM8607555","GSM8607554","GSM8607565","GSM8607576","GSM8607568","GSM8607557","GSM8607567","GSM8607556","GSM8607559","GSM8607569","GSM8607558"],"GPL":["29480"],"GSE":["280925"],"taxon":["Homo sapiens"]}}